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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EZH2
All Species:
28.79
Human Site:
Y325
Identified Species:
48.72
UniProt:
Q15910
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15910
NP_004447
746
85363
Y325
K
P
C
G
P
Q
C
Y
Q
H
L
E
G
A
K
Chimpanzee
Pan troglodytes
XP_001166174
754
86395
Y333
K
P
C
G
P
Q
C
Y
Q
H
L
E
G
A
K
Rhesus Macaque
Macaca mulatta
XP_001097572
895
101712
Y474
K
P
C
G
P
Q
C
Y
Q
H
L
E
G
A
K
Dog
Lupus familis
XP_532733
751
85949
C325
T
A
L
D
N
K
P
C
G
P
Q
C
Y
Q
H
Cat
Felis silvestris
Mouse
Mus musculus
Q61188
746
85318
Y325
K
P
C
G
P
Q
C
Y
Q
H
L
E
G
A
K
Rat
Rattus norvegicus
NP_001128451
746
85233
Y325
K
P
C
G
P
Q
C
Y
Q
H
L
E
G
A
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505650
747
85501
Y326
K
P
C
G
P
H
C
Y
Q
H
L
E
G
A
K
Chicken
Gallus gallus
XP_418879
766
87687
C340
T
A
L
D
N
K
P
C
G
P
H
C
Y
Q
H
Frog
Xenopus laevis
Q98SM3
748
85365
Y327
K
P
C
G
P
H
C
Y
Q
L
L
E
G
A
R
Zebra Danio
Brachydanio rerio
Q08BS4
760
87127
Y338
K
P
C
G
I
Y
C
Y
M
Y
M
V
Q
D
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42124
760
86917
K332
L
F
C
R
R
C
F
K
Y
D
C
F
L
H
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17514
773
88803
I328
G
F
K
A
E
I
P
I
E
F
P
N
G
E
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q8S4P4
895
100374
H361
M
E
S
G
T
V
S
H
K
V
D
V
S
I
M
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZSM8
856
95378
A349
S
S
D
V
P
H
A
A
A
S
G
V
S
L
Q
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
77.8
98.8
N.A.
98.2
98.2
N.A.
97.9
94.2
93
85
N.A.
48.5
N.A.
23.4
N.A.
Protein Similarity:
100
98.9
80.5
99.1
N.A.
99.1
99.1
N.A.
99.1
96
96.5
91.4
N.A.
62.2
N.A.
41.1
N.A.
P-Site Identity:
100
100
100
0
N.A.
100
100
N.A.
93.3
0
80
40
N.A.
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
6.6
N.A.
100
100
N.A.
93.3
6.6
86.6
53.3
N.A.
13.3
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
25.7
N.A.
27.4
N.A.
N.A.
Protein Similarity:
N.A.
44.1
N.A.
43.5
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
20
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
0
8
0
0
8
8
8
0
0
0
0
50
0
% A
% Cys:
0
0
65
0
0
8
58
15
0
0
8
15
0
0
0
% C
% Asp:
0
0
8
15
0
0
0
0
0
8
8
0
0
8
0
% D
% Glu:
0
8
0
0
8
0
0
0
8
0
0
50
0
8
0
% E
% Phe:
0
15
0
0
0
0
8
0
0
8
0
8
0
0
8
% F
% Gly:
8
0
0
65
0
0
0
0
15
0
8
0
58
0
8
% G
% His:
0
0
0
0
0
22
0
8
0
43
8
0
0
8
15
% H
% Ile:
0
0
0
0
8
8
0
8
0
0
0
0
0
8
0
% I
% Lys:
58
0
8
0
0
15
0
8
8
0
0
0
0
0
43
% K
% Leu:
8
0
15
0
0
0
0
0
0
8
50
0
8
8
0
% L
% Met:
8
0
0
0
0
0
0
0
8
0
8
0
0
0
8
% M
% Asn:
0
0
0
0
15
0
0
0
0
0
0
8
0
0
0
% N
% Pro:
0
58
0
0
58
0
22
0
0
15
8
0
0
0
0
% P
% Gln:
0
0
0
0
0
36
0
0
50
0
8
0
8
15
8
% Q
% Arg:
0
0
0
8
8
0
0
0
0
0
0
0
0
0
15
% R
% Ser:
8
8
8
0
0
0
8
0
0
8
0
0
15
0
0
% S
% Thr:
15
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
8
0
8
0
0
0
8
0
22
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
58
8
8
0
0
15
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _